Shakespeare might, of course, have written a tragedy about Brexit. It's a subject for a tragedy and farce because it's about lies, misunderstandings, feuds, boundaries, wars and ambitions all of which bring damage and death..
Shakespeare belongs to all humans because he wrote about the human condition.
Fundamentally Brexit is a reduction of humanity. Britons go from being important actors on a world stage to disappearing up their own ever diminishing island fundament. Scottish independence is the same. A diminution of what it is to be human from a universal respect for humanity to a populist jingoism.
Brexit if you must - but William Shakespeare belongs to the global village - all of humanity - he will never be part of Brexit.
I found this quote from a paper by Richard Wilson
"The Globe Theatre […] would have been for Shakespeare the pattern of the universe, the idea of the Macrocosm, the world stage on which the Microcosm acted his parts. All the world’s a stage." The words are in a real sense the clue to the Globe Theatre." It is by Juegen Schulz, ‘Maps as Metaphors: Mural Map Cycles of the Italian Renaissance’.
I borrowed this too -
The Settings of Shakespeare's Plays by Date for a chronology of the content of the plays.
All’s Well that Ends Well
Setting: Rousillon, Paris, Florence, and Marseilles
Antony and Cleopatra
Setting: Parts of the Roman Empire
As You Like It
Setting: Forest of Arden
The Comedy of Errors
Setting: Ephesus
Coriolanus
Setting: Rome, Corioli, and Antium
Cymbeline
Setting: Britain, Italy
Hamlet
Setting: Elsinore
Julius Caesar
Setting: Rome; afterwards, Sardis and near Philippi
King Lear
Setting: Britain
Love’s Labour’s Lost
Setting: Navarre
Macbeth
Setting: Scotland and England
Measure for Measure
Setting: Vienna
The Merchant of Venice
Setting: Partly in Venice, and partly at Belmont, the seat of Portia on the Continent
The Merry Wives of Windsor
Setting: Windsor
A Midsummer Night’s Dream
Setting: Athens, and a wood nearby
Much Ado about Nothing
Setting: Messina
Othello
Setting: Venice (for first act) and a sea-port in Cyprus
Pericles, Prince of Tyre
Setting: various countries
Romeo and Juliet
Setting: Verona and Mantua
The Taming of the Shrew
Setting: Sometimes in Padua, and sometimes in Petruchio's home in the country
The Tempest
Setting: The Sea; afterwards an Island
Timon of Athens
Setting: Athens
Setting: Rome
Troilus and Cressida
Setting: Troy
The Two Gentlemen of Verona
Setting: Verona, Milan, and the frontiers of Mantua
Twelfth Night
Setting: A city in Illyria, and the sea-coast nearby
The Winter’s Tale
Setting: Sometimes in Sicilia, sometimes in Bohemia
Go on then - Brexit - but you can't take Shakespeare away from the world, from Europe and from humanity - he won't fit into anything so small-minded even with Boris's putting all his weight onto it.